16 The 10 horns you saw, and the beast, will hate the prostitute. They will make her desolate and naked, devour her flesh, and burn her up with fire.
The Antichrist and his allies will betray the woman (the false religion). The beast will do this to get ultimate authority since the woman’s power rivals that of the beasts’.
17 For God has put it into their hearts to carry out His plan by having one purpose and to give their kingdom to the beast until God’s words are accomplished.
This phrase, “For God has put it into their hearts” does not suggest that God directs or manipulate men’s decisions. But, the Lord gives them up to their hearts decision according to Romans 1:24-26 which says, 24 Therefore God delivered them over in the cravings of their hearts to sexual impurity, so that their bodies were degraded among themselves. 25 They exchanged the truth of God for a lie, and worshiped and served something created instead of the Creator, who is praised forever. Amen. 26 This is why God delivered them over to degrading passions. For even their females exchanged natural sexual relations for unnatural ones.
The 10 horns (10 kings/nations) will exalt the Antichrist above them as their supreme leader.
18 And the woman you saw is the great city that has an empire over the kings of the earth.”
This false religion has a massive following of 1 billion people and has great influence with the leaders of the world.